7193. Pexiganan

Nomenclature

CAS number: 147664-63-9
7-l-Lysine-8-l-lysine-10-l-lysine-18-l-lysine-19-de-l-glutamic acid-21-l-leucine-23-l-lysinamide magainin I.
C122H210N32O22; mol wt 2477.17.
C 59.15%, H 8.54%, N 18.09%, O 14.21%.

Description and references

Synthetic, 22 amino acid peptide; analog of the magainins, q.v. Prepn: B. Berkowitz, L. Jacob, WO 9301723 (1993 to Magainin). In vitro antibacterial spectrum: Y. Ge et al., Diagn. Microbiol. Infect. Dis. 35, 45 (1999). Review of development: L. Jacob, M. Zasloff, Ciba Found. Symp. 186, 197-216 (1994); of structure-activity studies: W. L. Maloy, U. P. Kari, Biopolymers 37, 105-122 (1995); of pharmacology and clinical trials in diabetic foot ulcers: H. M. Lamb, L. R. Wiseman, Drugs 56, 1047-1052 (1998).

Chemical structure

Derivative

Acetate.

Nomenclature

CAS number: 172820-23-4
MSI-78; Locilex (Magainin).
C122H210N32O22.xC2H4O2.

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Peptides