12-07222. Penicillin G Benzhydrylamine [Archived]

Nomenclature

CAS number: 1538-11-0
[2S-(2α,5α,6β)]-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compd with α-phenylbenzenemethanamine (1:1); 1,1-diphenylmethylamine benzylpenicillinate; benzylpenicillin benzhydrylamine; benzhydrylamine penicillin; penicillin aminodiphenylmethane salt; benzylpenicillinic acid benzhydrylamine salt.
C29H31N3O4S; mol wt 517.64.
C 67.29%, H 6.04%, N 8.12%, O 12.36%, S 6.19%.
C16H18N2O4S.C13H13N.

Description and references

Semi-synthetic antibiotic. Prepd from potassium penicillin G and benzhydrylamine HCl in dil acetone: Hagemann et al., Ann. Pharm. Fr. 12, 565 (1954); Goldsmith et al., Antibiot. Chemother. 5, 648 (1955); Penau, Hagemann, US 2710863 (1955 to Labs. Francais de Chimiothérapie).

Properties

Crystals from dil acetone, mp 159°. [α]D20 +206° (c = 1). Soly in water at 24°: 0.7%. Insol in vegetable oils.

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Antibiotics); β-Lactams; Penicillins

Status

This monograph has been retired and is no longer subject to revision or update.