7202. Phenacaine Hydrochloride

Nomenclature

CAS number: 620-99-5
N,N′-Bis(4-ethoxyphenyl)ethanimidamide monohydrochloride; N1,N2-bis(p-ethoxyphenyl)acetamidine hydrochloride; Holocaine Hydrochloride (Winthrop).
C18H23ClN2O2; mol wt 334.84.
C 64.57%, H 6.92%, Cl 10.59%, N 8.37%, O 9.56%.

Description and references

Prepn: DE 79868; DE 80568.

Chemical structure

Derivative

Monohydrate.

Nomenclature

CAS number: 6153-19-1

Properties

Faintly bitter crystals producing transient numbness of the tongue. Stable in air. When anhydr, mp 190-192°. One gram dissolves in 50 ml water. Freely sol in boiling water, alcohol, chloroform. Insol in ether. Incompatible with alkalies and their carbonates and the usual alkaloidal reagents. Aq solns are stable and are not dec by boiling.

Therapeutic Category

Topical anesthetic (ophthalmic).

Therapeutic Category (Veterinary)

Ocular anesthetic.

Keywords

Anesthetic (Local)