7203. Phenacemide

Nomenclature

CAS number: 63-98-9
N-(Aminocarbonyl)benzeneacetamide; (phenylacetyl)urea; phenacetylurea; Epiclase (Bellon); Phacetur; Phenurone (Abbott); Phetylureum (Katwijk).
C9H10N2O2; mol wt 178.19.
C 60.66%, H 5.66%, N 15.72%, O 17.96%.

Description and references

Prepd by the action of aq NH3 on phenacetylurethan: Basterfield, Greig, Can. J. Res. 8, 454 (1933); of phenacetyl chloride on urea: Spielman et al., J. Am. Chem. Soc. 70, 4189 (1948). Toxicity study: K. Nakamura et al., Arzneim.-Forsch. 18, 524 (1968).

Chemical structure

Properties

Crystals from alcohol, mp 212-216°. Very slightly sol in water; slightly sol in alcohol, benzene, chloroform, ether. LD50 in mice, rats (mmol/kg): 5.54, >10 orally (Nakamura).

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant