7272. Phenyl Aminosalicylate

Nomenclature

CAS number: 133-11-9
4-Amino-2-hydroxybenzoic acid phenyl ester; p-aminosalicylic acid phenyl ester; phenyl p-aminosalicylic acid; p-aminosalol; fenamisal; Phenyl PAS; Pheny-PAS-Tebamin (Purdue Frederick); Tebamin; Tebanyl.
C13H11NO3; mol wt 229.23.
C 68.11%, H 4.84%, N 6.11%, O 20.94%.

Description and references

Description of properties: Meyer, Antibiot. Annu. 1957-1958, 614. Prepd by Raney nickel reduction of the corresp nitro ester in ethyl acetate: Friere, US 2604488 (1952 to Rh^one-Poulenc).

Chemical structure

Properties

Crystals from isopropanol, mp 153°. Soly in water: 0.7 mg/100 ml; in serum: 12 mg/100 ml. One gram of phenyl PAS is equivalent to 0.67 g PAS.

Therapeutic Category

Antibacterial (tuberculostatic).

Keywords

Antibacterial (Tuberculostatic)