7297. Phenyl Isothiocyanate

Nomenclature

CAS number: 103-72-0
Isothiocyanatobenzene; isothiocyanic acid phenyl ester; phenyl mustard oil; thiocarbanil.
C7H5NS; mol wt 135.19.
C 62.19%, H 3.73%, N 10.36%, S 23.72%.

Description and references

Prepd from ammonium phenyldithiocarbamate by the action of lead nitrate: Dains et al., Org. Synth. coll. vol. I (2nd ed., 1941) p 447.

Chemical structure

Properties

Liquid. mp -21°. d425 1.1288; d435 1.1202; d450 1.1061. bp760 221°; bp33 117.1°; bp12 95°. Distills with water without dec. nD23.4 1.64918. Insol in water. Sol in alcohol, ether.

Use

Derivatizing agent for primary, secondary amines. In sequencing of peptides by Edman degradation. In amino acid analyses by HPLC (Pico-Tag).