7324. PhIP
Nomenclature
Description and references
Most abundant of the mutagenic heterocyclic amines found in well-cooked meat and fish. Isoln from fried ground beef: J. S. Felton et al., Carcinogenesis 7, 1081 (1986). Synthesis: M. G. Knize, J. S. Felton, Heterocycles 24, 1815 (1986); T. Choshi et al., J. Org. Chem. 58, 7952 (1993); F. S. Bavetta et al., Tetrahedron Lett. 44, 7793 (1997). Mutagenicity in Chinese hamster ovary cells: L. H. Thompson et al., Mutagenesis 2, 483 (1987). Evaluation of carcinogenic risk: IARC Monographs 56, 229-242 (1993). Review of bioavailability, content in foods, metabolism: N. J. Gooderham et al., Br. J. Clin. Pharmacol. 42, 91-98 (1996). Correlation of dietary intake with breast cancer risk: R. Sinha et al., J. Natl. Cancer Inst. 92, 1352 (2000).
