7381. Physalaemin
Nomenclature
Description and references
An undecapeptide belonging to the group of proteins named tachykinins. Found in skin of the amphibian Physalaemus fuscumaculatus: Erspamer et al., Experientia 18, 562 (1962). Structure: Erspamer et al., ibid. 20, 489 (1964); Anastasi et al., Arch. Biochem. Biophys. 108, 341 (1964). Synthesis: Bernardi et al., Experientia 20, 490 (1964); Nakamura et al., JP 71 25384 (1971 to Dainippon), C.A. 75, 152083r (1971). Solid-phase synthesis: W. Voelter et al., Tetrahedron 28, 5963 (1972). Biological activities similar to the tachykinins eledoisin and substance P, q.q.v. Exerts a powerful hypotensive action, stimulates salivary secretion, intestinal contraction, and vasodilation. Occurrence in other Physalaemus spp. and pharmacology: G. Bertaccini et al., Br. J. Pharmacol. 25, 363 (1965); G. Bertaccini, Pharmacol. Rev. 28, 127 (1976). Differentiation of physalaemin and substance P: Geipert et al., Arch. Pharmacol. 265, 225 (1969). Immunoreactivity study in human lung small-cell carcinoma: L. H. Lazarus et al., Science 219, 79 (1983).
