7406. Picosulfate Sodium

Nomenclature

CAS number: 10040-45-6
4,4′-(2-Pyridinylmethylene)bisphenol bis(hydrogen sulfate) (ester) disodium salt; 4,4′-(2-pyridylmethylene)diphenolbis(hydrogen sulfate) (ester) disodium salt; 4,4′-(2-picolylidene)bis(phenylsulfuric acid) disodium salt; 2-picolylidenebis(p-phenyl sodium sulfate); disodium 4,4′-disulfoxydiphenyl-(2-pyridyl)methane; picosulfol; sodium picosulfate; Guttalax-Fher (Boehringer, Ing., Italia); Laxoberal (Boehringer, Ing.); Laxoberon (Ferrosan); Neopax (Janssen); Pico-Salax (Ferring).
C18H13NNa2O8S2; mol wt 481.41.
C 44.91%, H 2.72%, N 2.91%, Na 9.55%, O 26.59%, S 13.32%.

Description and references

Prepn: Pala, FR M5832 and US 3528986, US 3558643 (1968, 1970, 1971 all to Ist. de Angeli); Seeger, Machleidt, DE 1904322 (1970 to Thomae). Synthesis and physical-chemical data: Pala et al., Helv. Chim. Acta 51, 1164 (1968). Pharmacology: Pala et al., Arch. Int. Pharmacodyn. Ther. 164, 356 (1966). Metabolism: Perego et al., Arzneim.-Forsch. 19, 1889 (1969).

Chemical structure

Properties

White crystalline solid from ethanol or methanol, mp 272- 275° (dec). uv max (H2O): 218, 262 nm (ε 20450, 6075). Readily sol in water; slightly sol in alcohol. Practically insol in most organic solvents.

Therapeutic Category

Cathartic.

Keywords

Laxative/Cathartic