7407. Picotamide
Nomenclature
CAS number: 32828-81-2
4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide; 4-methoxy-N,N′-bis(3-pyridylmethyl)isophthalamide; N,N′-bis(3-picolyl)-4-methoxyisophthalamide; G-137. C21H20N4O3; mol wt 376.41.
C 67.01%, H 5.36%, N 14.88%, O 12.75%.
Description and references
Prepn: R. Selleri et al., Chim. Ther. 6, 203 (1971); G. Orzalesi, R. Selleri, FR 2100850 C.A. 77, 164502f (1972); prepn and use as inhibitor of blood platelet aggregation: eidem, US 3973026 (1972, 1976 both to Soc. Italo-Brit. L. Manetti-H. Roberts). Crystal structure of monohydrate: E. Foresti et al., Acta Crystallogr. C42, 220 (1986). Mechanism of action study: M. Berrettini et al., Boll. Soc. Ital. Biol. Sper. 59, 309 (1983). Clinical studies: R. Schmutzler et al., Age Ageing 7, 246 (1978); V. Coto et al., Minerva Cardioangiol. 34, 601 (1986).
Properties
Crystalline powder from benzene, mp 124°. LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976).Derivative
Monohydrate.Nomenclature
CAS number: 80530-63-8
Plactidil (Novartis). C21H20N4O3.H2O; mol wt 394.42.
C 63.95%, H 5.62%, N 14.20%, O 16.23%.
Therapeutic Category
Antithrombotic; fibrinolytic; anticoagulant.
Keywords
Anticoagulant; Antithrombotic