7455. Pipamperone

Nomenclature

CAS number: 1893-33-0
1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide; 1′-[3-(p-fluorobenzoyl)propyl]-[1,4′-bipiperidine]-4′-carboxamide; 1-(p-fluorophenyl)-4-(4-piperidino-4-carbamoylpiperidino)-1-butanone; 1-[γ-(4-fluorobenzoyl)propyl]-4-piperidinopiperidine-4-carboxamide; 4′-fluoro-4-[N-[4-(N-piperidino)-4-carbamido]piperidino]butyrophenone; floropipamide; R-3345.
C21H30FN3O2; mol wt 375.48.
C 67.17%, H 8.05%, F 5.06%, N 11.19%, O 8.52%.

Description and references

Prepn of the dihydrochloride by reaction of γ-chloro-4-fluorobutyrophenone and 4-piperidinopiperidine-4-carboxamide: Janssen, BE 610830 (1962 to Janssen), C.A. 57, 13740b (1962).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 2448-68-2
Dipiperon (Janssen); Piperonil (Lusofarmaco); Propitan (Eisai).
C21H30FN3O2.2HCl; mol wt 448.40.
C 56.25%, H 7.19%, F 4.24%, N 9.37%, O 7.14%, Cl 15.81%.

Properties

Crystals, mp 124.5-126.0°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Butyrophenones