7456. Pipazethate
Nomenclature
CAS number: 2167-85-3
10H-Pyrido[3,2-b][1,4]benzothiadiazine-10-carboxylic
acid 2-(2-piperidinoethoxy)ethyl ester; 2-(2-piperidinoethoxy)ethyl 10H-pyrido[3,2-b][1,4]benzothiadiazine-10-carboxylate; thiophenylpyridylamino-10-carboxylic acid piperidinoethoxyethyl
ester; 2-(2-piperidinoethoxy)ethyl 10-thia-1,9-diazaanthracene-10-carboxylate; 1-azaphenothiazine-10-carboxylic acid 2-(2-piperidinoethoxy)ethyl
ester; D-254. C21H25N3O3S; mol wt 399.51.
C 63.13%, H 6.31%, N 10.52%, O 12.01%, S 8.03%.
Description and references
Prepn: Schuler et al., Ann. 673, 102 (1964); Schuler, US 2989529 (1961 to Degussa).
Derivative
Hydrochloride.Nomenclature
CAS number: 6056-11-7
Lenopect (Draco); Selvigon (ICN-Galenika); Selvjgon (Rorer); Theratuss (Squibb). C21H25N3O3S.HCl; mol wt 435.97.
C 57.85%, H 6.01%, N 9.64%, O 11.01%, S 7.35%, Cl 8.13%.
Properties
Pale yellow crystals from isopropanol, mp 160-161°. Soluble in water, methanol. Practically insol in acetone, petr ether. LD50 orally in rats: 560 mg/kg (Schuler).Therapeutic Category
Antitussive.
Keywords
Antitussive