7459. Pipecurium Bromide

Nomenclature

CAS number: 52212-02-9
4,4′-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis(1,1-dimethylpiperazinium)dibromide; 4,4′-(3α,17β-dihydroxy-5α-androstan-2β,16β-ylene)bis(1,1-dimethylpiperazinium)dibromide diacetate; pipecuronium bromide; RGH-1106; Arduan (Organon).
C35H62Br2N4O4; mol wt 762.70.
C 55.12%, H 8.19%, Br 20.95%, N 7.35%, O 8.39%.

Description and references

Aminosteroid, competitive neuromuscular blocker. Prepn: Z. Tuba et al., DE 2337882 (1974 to Gedeon Richter), C.A. 80, 121210d (1974); Z. Tuba, Arzneim.-Forsch. 30, 342 (1980). Toxicity study: E. Kárpáti, K. Biro, ibid. 346. Series of articles on pharmacology, properties, disposition, pharmacokinetics, safety tests, clinical studies: ibid. 346-394. Determn in human serum: G. Szabo, E. Tassonyi, ibid. 31, 1013 (1981).

Chemical structure

Properties

Crystals from methylene dichloride/acetone, mp 262-264° (dec). [α]D25 +8.1° (c = 1 in water). LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro).

Therapeutic Category

Neuromuscular blocking agent.

Keywords

Neuromuscular Blocking Agent; Nondepolarizing Agents