7480. Pipobroman

Nomenclature

CAS number: 54-91-1
1,4-Bis-(3-bromo-1-oxopropyl)piperazine; 1,4-bis-(3-bromopropionyl)piperazine; A-8103; NSC-25154; Amedel (Dainippon); Vercyte (Abbott).
C10H16Br2N2O2; mol wt 356.05.
C 33.73%, H 4.53%, Br 44.88%, N 7.87%, O 8.99%.

Description and references

Prepn: Horrom, Carbon, DE 1138781 (1962 to Abbott), C.A. 58, 7955c (1963); Groszkowski, Rocz. Chem. 38, 229 (1964), C.A. 60, 14506a (1964). Structure-cytostatic effect studies: Groszkowski et al., J. Med. Chem. 11, 621 (1968); Oteleanu, Retezeanu, Farmacia (Bucharest) 16, 279 (1968), C.A. 69, 33591w (1968).

Chemical structure

Properties

Crystals, mp 106-107°.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkylating Agents