7482. Pipotiazine

Nomenclature

CAS number: 39860-99-6
10-[3-[4-(2-Hydroxyethyl)-1-piperidinyl]propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide; 2-[1-[3-[2-[(dimethylamino)sulfonyl]-10H-phenothiazin-10-yl]propyl]-4-piperidinyl]ethanol; pipothiazine; RP-19366; Piportil (Specia).
C24H33N3O3S2; mol wt 475.67.
C 60.60%, H 6.99%, N 8.83%, O 10.09%, S 13.48%.

Description and references

Prepn: FR M7835 (1970 to Rh^one-Poulenc), C.A. 78, 43499x (1973). Pharmacokinetics: P. J. De Schepper et al., Arzneim.-Forsch. 29, 1056 (1979); and HPLC determn in plasma: D. A. Ogden et al., J. Pharm. Biomed. Anal. 7, 1273 (1989). Series of articles on pharmacology and clinical use: Acta Psychiat. Scand., Suppl. 241, 9-138 (1973). Toxicity: L. Julou et al., ibid. 9.

Chemical structure

Properties

LD50 in mice (mg/kg): 108 i.p.; 360 s.c.; 440 orally (Julou).

Derivative

Palmitic ester.

Nomenclature

CAS number: 37517-26-3
Pipotiazine palmitate; RP-19552; Piportil L4 (Specia).
C40H63N3O4S2; mol wt 714.08.
C 67.28%, H 8.89%, N 5.88%, O 8.96%, S 8.98%.

Derivative

Undecylenic ester.

Nomenclature

CAS number: 22178-11-6
Pipotiazine undecylenate; RP-19551; Piportil M2 (Specia).
C35H51N3O4S2; mol wt 641.93.
C 65.49%, H 8.01%, N 6.55%, O 9.97%, S 9.99%.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Phenothiazines