7495. Pirifibrate

Nomenclature

CAS number: 55285-45-5
2-(4-Chlorophenoxy)-2-methylpropanoic acid [6-(hydroxymethyl)-2-pyridinyl]methyl ester; 2,6-pyridinedimethanol mono-p-chlorophenoxyisobutyrate; EL-466; Bratenol (Elmu).
C17H18ClNO4; mol wt 335.78.
C 60.81%, H 5.40%, Cl 10.56%, N 4.17%, O 19.06%.

Description and references

Hypolipemic agent related structurally to clofibrate, q.v. Prepn: D. Humbert, R. Ratouis, DE 2432322; eidem, US 3971798 (1975, 1976 both to Roussel). Multicenter study in hyperlipoproteinemias: A. J. Domingo et al., Clin. Ther. 3, 219 (1980).

Chemical structure

Properties

Crystals from isopropyl ether, mp 46°. LD50 in mice (mg/kg): 915-1098 i.p. (Humbert, Ratouis, 1975).

Derivative

Hydrochloride.
C17H18ClNO4.HCl; mol wt 372.24.
C 54.85%, H 5.14%, Cl 19.05%, N 3.76%, O 17.19%.

Properties

Crystals, mp 110°. LD50 (calculated as base) in mice (mg/kg): 1098-1281 i.p. (Humbert, Ratouis, 1975).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates