7516. Plafibride

Nomenclature

CAS number: 63394-05-8
2-(4-Chlorophenoxy)-2-methyl-N-[[(4-morpholinylmethyl)amino]carbonyl]propanamide; N-2-(p-chlorophenoxy)isobutyryl-N′-morpholinomethylurea; ITA-104; Idonor (Roger); Perifunal (Aristegui).
C16H22ClN3O4; mol wt 355.82.
C 54.01%, H 6.23%, Cl 9.96%, N 11.81%, O 17.99%.

Description and references

Analog of clofibrate, q.v. Prepn: J. Iniesta-Pons, DE 2716374 (1977 to Investigacion Tecnica y Aplicada), C.A. 88, 37810g (1978). Toxicity data: J. Zapatero, L. Brugeghini, Arch. Farmacol. Toxicol. 4, 137 (1978). Series of articles on antiplatelet aggregation activity, hypolipemic activity, pharmacology, and toxicology: ibid. 132-142.

Chemical structure

Properties

Crystals, mp 100-102°. Sol in acetone. Slightly sol in alcohol. Practically insol in water, petr ether. LD50 in mice, rats, guinea pigs (mg/kg): 3569, >4000, 2168 orally (Zapatero, Brugeghini).

Therapeutic Category

Antithrombotic.

Keywords

Antithrombotic