7522. Plasmocid

Nomenclature

CAS number: 551-01-9
N,N-Diethyl-N′-(6-methoxy-8-quinolinyl)-1,3-propanediamine; 8-(3-diethylaminopropylamino)-6-methoxyquinoline; 6-methoxy-8-(3-diethylaminopropylamino)quinoline; 710-F; SN-3115; Fourneau 710; Antimalarine; Rhodoquine.
C17H25N3O; mol wt 287.40.
C 71.04%, H 8.77%, N 14.62%, O 5.57%.

Description and references

Prepn: Fourneau et al., Ann. Inst. Pasteur 44, 503 (1930); 46, 514 (1931); 50, 731 (1933); Magidson, Strukov, Arch. Pharm. 271, 359 (1933); Strukov, SU 39105 (1934), C.A. 30, 3445 (1936); Magidson et al., J. Appl. Chem. USSR 9, 304 (1936); Giral, Ciencia (Mexico City) 6, 253 (1945), C.A. 40, 3563 (1946); Yanko et al., J. Am. Chem. Soc. 67, 664 (1945).

Chemical structure

Properties

Oily liquid, d424 1.0569. bp1.0 182°. nD24 1.5855.

Derivative

Dihydrochloride.
C17H27Cl2N3O; mol wt 360.32.
C 56.67%, H 7.55%, Cl 19.68%, N 11.66%, O 4.44%.

Properties

Yellow crystals, mp 218-220°. Slightly sol in water, alcohol.

Derivative

Diphosphate.

Properties

Yellow crystals, mp 169-171°. Slightly sol in water, alcohol.

Note

The name Rhodoquine was first applied to 8-(3-dimethylaminopropylamino)-6-methoxyquinoline.

Therapeutic Category

Antimalarial.

Keywords

Antimalarial