7575. Polyoxidonium

Description and references

Immunostimulant copolymer of N-oxidized 1,4-ethylenepiperazine and (N-carboxyethyl)-1,4-ethylenepiperazine bromide; mol wt 60-100 kDa. Prepn: R. V. Petrov et al., WO 9507100; A. V. Nekrasov et al., US 5503830 (1995, 1996 both to Petrovax). Adjuvant activity in mice: K. S. Nandakumar, V. R. Muthukkaruppan, Scand. J. Immunol. 50, 188 (1999). Effect on human peripheral blood leukocytes: V. A. Dyakonova et al., Int. Immunopharmacol. 4, 1615 (2004). Review of development and use in influenza vaccine: V. A. Kabanov, Pure Appl. Chem. 76, 1659-1677 (2004).

Properties