7584. Polythiazide

Nomenclature

CAS number: 346-18-9
6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 2-methyl-3-(β,β,β-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; Drenusil (Pfizer); Nephril (Pfizer); Renese (Pfizer).
C11H13ClF3N3O4S3; mol wt 439.88.
C 30.03%, H 2.98%, Cl 8.06%, F 12.96%, N 9.55%, O 14.55%, S 21.87%.

Description and references

Prepn: J. M. McManus, US 3009911 (1961 to Pfizer). Comprehensive description: T. Negendra Varo Prasad, Anal. Profiles Drug Subs. 20, 665-692 (1991).

Chemical structure

Properties

Crystals from isopropanol, mp 202.5°. Sol in methanol and acetone. Practically insol in water and chloroform. Sol in aq solns made alkaline with carbonates or hydroxides of the alkali metals. Rate of decompn increases with increase in pH.

Therapeutic Category

Diuretic, antihypertensive.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs