7706. Pramiracetam

Nomenclature

CAS number: 68497-62-1
N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide; N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide; amacetam.
C14H27N3O2; mol wt 269.38.
C 62.42%, H 10.10%, N 15.60%, O 11.88%.

Description and references

Cognition enhancer structurally related to piracetam, q.v. Prepn: Y. J. L'Italien, I. C. Nordin, DE 2808067; eidem, US 4145347 (1978, 1979 both to Parke, Davis); D. E. Butler et al., J. Med. Chem. 27, 684 (1984). Pharmacology: B. P. H. Poschel et al., Drugs Exp. Clin. Res. 9, 853 (1983). GC determn in plasma: T. Chang, R. M. Young, J. Chromatogr. 274, 346 (1983). Clinical pharmacokinetics: T. Chang et al., J. Clin. Pharmacol. 25, 291 (1985). Clinical evaluation in Alzheimer's disease: R. J. Branconnier et al., Psychopharmacol. Bull. 19, 726 (1983); in various cognitive disorders: R. Dejong, Curr. Ther. Res. 41, 254 (1987).

Chemical structure

Properties

bp0.15 162-164°. Monohydrate, mp 47-48°.

Derivative

Sulfate.

Nomenclature

CAS number: 72869-16-0
CI-879.
C14H27N3O2.H2SO4; mol wt 367.46.
C 45.76%, H 7.95%, N 11.44%, O 26.12%, S 8.73%.

Properties

LD50 in male, female mice (mg/kg): 5434, 4355 orally (Poschel).

Therapeutic Category

Nootropic.

Keywords

Nootropic