7707. Pramiverin

Nomenclature

CAS number: 14334-40-8
N-(1-Methylethyl)-4,4-diphenylcyclohexanamine; N-isopropyl-4,4-diphenylcyclohexylamine; pramiverine; primaverine; propaminodiphen.
C21H27N; mol wt 293.45.
C 85.95%, H 9.27%, N 4.77%.

Description and references

Prepn: NL 6515046; R. Unger et al., US 3376312 (1966, 1968 both to E. Merck). Pharmacology: H. J. Enenkel et al., Arzneim.-Forsch. 26, 690 (1976). Toxicological study: M. Von Eberstein et al., ibid. 703. Series of articles on pharmacology, pharmacokinetics, GC determn, clinical studies: ibid. 686-752. Use in management of labor: G. LoDico et al., Minerva Ginecol. 31, 683 (1979).

Chemical structure

Properties

Liq, bp0.05 164-165°; also reported as a solid, mp 70° (Enenkel).

Derivative

Hydrochloride.

Nomenclature

CAS number: 14334-41-9
EMD-9806; HSP-2986; Monoverin (Merck KGaA); Sistalgin (Merck KGaA).
C21H27N.HCl; mol wt 329.91.
C 76.45%, H 8.55%, N 4.25%, Cl 10.75%.

Properties

Off-white crystalline powder, mp 230°; also reported as 234-237° (Enenkel). Soly at 25° (g/100 ml): in water 0.3; in ethanol 4; in chloroform 5. Practically insol in ether. LD50 (after 14 days) in mice, rats (mg/kg): 346, 623 orally; 25, 26 i.v. (Von Eberstein).

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic