7709. Pramoxine

Nomenclature

CAS number: 140-65-8
4-[3-(4-Butoxyphenoxy)propyl]morpholine; p-butoxyphenyl γ-morpholinopropyl ether; γ-morpholinopropyl 4-n-butoxyphenyl ether; pramocaine; proxazocain.
C17H27NO3; mol wt 293.40.
C 69.59%, H 9.28%, N 4.77%, O 16.36%.

Description and references

Prepn: Wright, Moore, J. Am. Chem. Soc. 73, 2281 (1951); 76, 4396 (1954); US 2870151 (1959 to Abbott). Pharmacology: O. Blanpin, Anesth. Analg. Reanimat. 14, 225 (1957). Toxicity studies: J. L. Schmidt et al., Toxicol. Appl. Pharmacol. 1, 454 (1959); S. Monash, D. Gibbs, Anesth. Analg. 38, 265 (1959).

Chemical structure

Properties

bp6 196°; bp2.8 183-184°. LD50 in mice (mg/kg): 300 i.p., 900 s.c. (Monash, Gibbs).

Derivative

Hydrochloride.

Nomenclature

CAS number: 637-58-1
Proctofoam-NS (Schwarz); Tronolane (Abbott); Tronothane (Abbott).
C17H27NO3.HCl; mol wt 329.86.
C 61.90%, H 8.56%, N 4.25%, O 14.55%, Cl 10.75%.

Properties

Crystals, mp 181-183°. Sol in water. LD50 i.v. in mice: 79.5 ±2.7 mg/kg (Schmidt). LD50 in mice (mg/kg): 300 i.p., 750 s.c. (Monash, Gibbs).

Therapeutic Category

Anesthetic (local).

Keywords

Anesthetic (Local)