7708. Pramlintide

Nomenclature

CAS number: 151126-32-8
25-l-Proline-28-l-proline-29-l-proline-amylin (human); tripro-amylin; AC-137; Symlin (Amylin).
C171H267N51O53S2; mol wt 3949.39.
C 52.00%, H 6.81%, N 18.09%, O 21.47%, S 1.62%.

Description and references

Analog of human amylin, q.v. Prepn: L. S. L. Gaeta et al., WO 9310146; eidem, US 5686411 (1993, 1997 both to Amylin Pharm.). Pharmacology: A. A. Young et al., Drug Dev. Res. 37, 231 (1996). Clinical pharmacokinetics, pharmacodynamics: W. A. Colburn et al., J. Clin. Pharmacol. 36, 13 (1996). Clinical evaluation in insulin-dependent diabetes: O. G. Kolterman et al., Diabetologia 39, 492 (1996).

Chemical structure

Therapeutic Category

In treatment of insulin-dependent diabetes.

Keywords

Antidiabetic; Hormones/Analogs