7736. Prenoxdiazine Hydrochloride

Nomenclature

CAS number: 982-43-4
1-[2-[3-(2,2-Diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl]piperidine monohydrochloride; 3-(β,β-diphenylethyl)-5-(β-piperidinoethyl)-1,2,4-oxadiazole hydrochloride; HK-256; Libexin (Chinoin); Lomapect (TAD); Tibexin (Christiaens).
C23H28ClN3O; mol wt 397.94.
C 69.42%, H 7.09%, Cl 8.91%, N 10.56%, O 4.02%.

Description and references

Prepn: K. Harsanyi et al., HU 151748 (1964 to Chinoin), C.A. 62, 11821f (1965). Pharmacology: L. Tardos, I. Erdély, Arzneim.-Forsch. 16, 617 (1966). Stability study: E. Pandula et al., Acta Pharm. Hung. 38, 68 (1968). Review of pharmacology and clinical studies: K. Harsanyi et al., Boll. Chim. Farm. 112, 691 (1973).

Chemical structure

Properties

Crystals from ethanol, mp 192-193°. LD50 in mice, rats (mg/kg): 920, >2000 orally; 34, 32 i.v. (Tardos, Erdély).

Therapeutic Category

Antitussive.

Keywords

Antitussive