7737. Prenylamine
Nomenclature
CAS number: 390-64-7
N-(1-Methyl-2-phenylethyl)-γ-phenylbenzenepropanamine; N-(3,3-diphenylpropyl)-α-methylphenethylamine; N-(3′-phenyl-2′-propyl)-1,1-diphenyl-3-propylamine; 1-phenyl-2-[1′,1′-diphenylpropyl-3′-amino]propane; B-436; Elecor (Galenica). C24H27N; mol wt 329.48.
C 87.49%, H 8.26%, N 4.25%.
Description and references
Prepn: G. Ehrhart et al., DE 1100031 C.A. 56, 3413h (1962) and DE 1111642 corresp to US 3152173 (1961, 1961, 1964 all to Hoechst); G. Erhart, Arch. Pharm. 295, 196 (1962). Series of articles on pharmacology and chemistry: Arzneim.-Forsch. 10, 569-588 (1960). Metabolism: M. Volz, ibid. 21, 1320 (1971). Review: J. E. Murphy, J. Int. Med. Res. 1, 204-209 (1973).
Properties
mp 36.5-37.5°.Derivative
Lactate.Nomenclature
CAS number: 69-43-2
Angormin (Unifa); Bismetin (Mect); Carditin-Same (Savoma); Coredamin (Meiji); Corontin (Chinoin); Crepasin (Hoei); Daxauten (3M Pharma); Hostaginan (Hoechst); Incoran (ITA); Irrorin; Lactamin (Teisan); Plactamin (Morishita); Reocorin (Farmochimica); Roinin (Mohan); Seccidin (Nippon Kayaku); Sedolatan (Hoechst); Segontin (Hoechst); Synadrin (Hoechst). C27H33NO3; mol wt 419.56.
C 77.29%, H 7.93%, N 3.34%, O 11.44%.
Properties
mp 140-142°. Sparingly sol in water (≈0.5%); sol in organic solvents. uv max (chloroform): 260 nm (E1%1cm 170).Therapeutic Category
Vasodilator (coronary).
Keywords
Calcium Channel Blocker; Arylalkylamines; Vasodilator (Coronary)