7756. Procainamide Hydrochloride

Nomenclature

CAS number: 614-39-1
4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride; procaine amide hydrochloride; Amisalin (Daiichi); Novocamid (Hoechst); Procamide (Sintesa); Procanbid (Parke-Davis); Procan-SR (Parke-Davis); Procapan (Panray); Pronestyl (BMS).
C13H22ClN3O; mol wt 271.79.
C 57.45%, H 8.16%, Cl 13.04%, N 15.46%, O 5.89%.

Description and references

Prepn: M. Yamazaki et al., J. Pharm. Soc. Jpn. 73, 294 (1953); Y. Tashika, M. Kuranari, ibid. 1069. Comprehensive description: R. B. Poet, H. Kadin, Anal. Profiles Drug Subs. 4, 333-383 (1975).

Chemical structure

Properties

Crystals, mp 165-169°. uv max: 278 nm. Freely sol in water. Sol in alc; slightly sol in chloroform; very sparingly sol in benzene, ether. The pH of a 10% aq soln is 5.5.

Therapeutic Category

Antiarrhythmic (class IA).

Keywords

Antiarrhythmic