7775. Proglumide

Nomenclature

CAS number: 6620-60-6
4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid; dl-4-benzamido-N,N-dipropylglutaramic acid; N-benzoyl-N′,N′-di-n-propyl-dl-isoglutamine; xylamide; CR-242; W-5219; Milid (Opfermann); Milide (Beytout); Promid (Kaken).
C18H26N2O4; mol wt 334.41.
C 64.65%, H 7.84%, N 8.38%, O 19.14%.

Description and references

Prepn: NL 6510006; ZA 6504065 (both 1966 to Rotta), C.A. 65, 3793b (1966). Pharmacological activity: A. L. Rovati et al., Minerva Med. 58, 3653 (1967); T. Umetzu et al., Eur. J. Pharmacol. 64, 69 (1980). Pharmacokinetic study: A. A. Bignamini et al., Arzneim.-Forsch. 29, 639 (1979). Clinical study in duodenal ulcer: W. Bergemann et al., Med. Klin. 76, 226 (1981). Cholecystokinin receptor antagonist activity: W. F. Hahne et al., Proc. Natl. Acad. Sci. USA 78, 6304 (1981). Selective blockade of cholecystokinin CNS effects: L. A. Chiodo, B. S. Bunney, Science 219, 1449 (1983).

Chemical structure

Properties

Crystals, mp 142-145°. LD50 in mice (mg/kg): 2211-2649 i.v.; 7350-8861 orally (Rovati).

Therapeutic Category

Anticholinergic.

Keywords

CCK Antagonist