7895. Protokylol

Nomenclature

CAS number: 136-70-9
4-[2-[[2-(1,3-Benzodioxol-5-yl)-1-methylethyl]amino]-1-hydroxyethyl]-1,2-benzenediol; α-[(α-methyl-3,4-methylenedioxyphenethylamino)methyl]protocatechuyl alcohol; α-(3,4-dihydroxyphenyl)-β-[2-(3,4-methylenedioxyphenyl)isopropylamino]ethanol; 1-(3,4-dihydroxyphenyl)-2-(α-methyl-3,4-methylenedioxyphenethylamino)ethanol; N-[β-(3,4-methylenedioxyphenyl)isopropyl]-β-(3,4-dihydroxyphenyl)-β-hydroxyethylamine; N-[2-(3,4-methylenedioxyphenylisopropyl)]norepinephrine.
C18H21NO5; mol wt 331.36.
C 65.24%, H 6.39%, N 4.23%, O 24.14%.

Description and references

β-Adrenergic agonist. Prepn: Biel et al., J. Am. Chem. Soc. 76, 3149 (1954); Biel, US 2900415 (1959 to Lakeside Labs.). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 136-69-6
JB-251; Caytine; Ventaire.
C18H21NO5.HCl; mol wt 367.82.
C 58.78%, H 6.03%, N 3.81%, O 21.75%, Cl 9.64%.

Properties

Crystals from isopropanol, mp 126-127°. Sol in water. LD50 orally in rats: 938 ±96 mg/kg (Goldenthal).

Therapeutic Category

Bronchodilator.

Therapeutic Category (Veterinary)

Bronchodilator.

Keywords

β-Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives