7907. Prucalopride

Nomenclature

CAS number: 179474-81-8
4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide; R-93877; Resolor (J & J).
C18H26ClN3O3; mol wt 367.87.
C 58.77%, H 7.12%, Cl 9.64%, N 11.42%, O 13.05%.

Description and references

Benzofuran derivative; specific serotonin 5-HT4 receptor agonist. Prepn: G. H. P. Van Daele et al., WO 9616060; eidem, US 5854260 (1996, 1998 both to Janssen). Effect on isolated gastrointestinal muscle: N. H. Prins et al., Br. J. Pharmacol. 127, 1431 (1999). Clinical stimulation of colonic transit: E. P. Bouras et al., Gut 44, 682 (1999).

Chemical structure

Properties

Monohydrate, mp 90.7°.

Therapeutic Category

Gastroprokinetic.

Keywords

Gastroprokinetic