7933. Pteroic Acid

Nomenclature

CAS number: 119-24-4
4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid; p-[(2-amino-4-hydroxy-6-pteridylmethyl)amino]benzoic acid.
C14H12N6O3; mol wt 312.28.
C 53.85%, H 3.87%, N 26.91%, O 15.37%.

Description and references

Intermediate in the synthesis of folic acids. Prepn: Waller et al., J. Am. Chem. Soc. 70, 19 (1948); cf. Hultquist et al., ibid. 23; Boothe, US 2472462 (1949 to Am. Cyanamid); C. Temple et al., J. Org. Chem. 46, 3666 (1981). Synthesis: M. G. Nair et al., ibid. 3152.

Chemical structure

Properties

Crystals from dil HCl. Sol in aq NaOH solns.