7978. Pyridoxal

Nomenclature

CAS number: 66-72-8
3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde; 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde; 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine.
C8H9NO3; mol wt 167.16.
C 57.48%, H 5.43%, N 8.38%, O 28.71%.

Description and references

Synthesis and structure: Harris et al., J. Biol. Chem. 154, 315 (1944); J. Am. Chem. Soc. 66, 2088 (1944).

Chemical structure

Derivative

Hydrochloride.
C8H9NO3.HCl; mol wt 203.62.
C 47.19%, H 4.95%, N 6.88%, O 23.57%, Cl 17.41%.

Properties

Rhombic crystals, mp approx 165° with decompn. Soluble in water (1 g/2 ml); sol in 95% ethanol (1.7 g/100 ml); pH of 1% water soln = 2.65. The water solns are sensitive to heat. uv max: 292.5 nm (E mol 7600). Can be reduced to pyridoxine hydrochloride (mp 206-208°).

Derivative

Monoethylacetal hydrochloride.

Nomenclature

1,3-Dihydro-1-ethoxy-6-methylfuro[3,4-c]pyridin-7-ol hydrochloride.
C10H14ClNO3; mol wt 231.68.
C 51.84%, H 6.09%, Cl 15.30%, N 6.05%, O 20.72%.

Properties

Crystals from alcohol and ether, mp 142-143°.