8056. Quinethazone

Nomenclature

CAS number: 73-49-4
7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide; 7-chloro-2-ethyl-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone; 7-chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-sulfamoylquinazoline; CL-36010; Hydromox (Lederle); Aquamox (Lederle).
C10H12ClN3O3S; mol wt 289.74.
C 41.45%, H 4.17%, Cl 12.24%, N 14.50%, O 16.57%, S 11.07%.

Description and references

Prepn: Cohen et al., J. Am. Chem. Soc. 82, 2731 (1960); Cohen, Vaughan, Jr., US 2976289 (1961 to Am. Cyanamid).

Chemical structure

Properties

Fibrous crystals from 50% acetone, mp 250-252°. Sol in acetone, alcohol.

Therapeutic Category

Diuretic, antihypertensive.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs