8097. Rafoxanide

Nomenclature

CAS number: 22662-39-1
N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide; 3′-chloro-4′-(p-chlorophenoxy)-3,5-diiodosalicylanilide; MK-990; Flukanide (Merck & Co.); Ranide (Merck & Co.).
C19H11Cl2I2NO3; mol wt 626.01.
C 36.45%, H 1.77%, Cl 11.33%, I 40.54%, N 2.24%, O 7.67%.

Description and references

Prepn: NL 6815783; BE 724668 (both 1969 to Merck & Co.); Mrozik et al., Experientia 25, 883 (1969). Trials in sheep and cattle: Snijders, Horak, Louw, J. S. Afr. Vet. Med. Assoc. 43, 397 (1972); 44, 251 (1973); 46, 265 (1975); Horak, Snijders, Vet. Rec. 94, 12 (1974).

Chemical structure

Properties

Crystals, mp 168-170°. Moderately sol in acetone and acetonitrile. Practically insol in water.

Therapeutic Category (Veterinary)

Fasciolicide; anthelmintic.