8121. Ravuconazole

Nomenclature

CAS number: 182760-06-1
4-[2-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile; (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol; BMS-207147; ER-30346.
C22H17F2N5OS; mol wt 437.47.
C 60.40%, H 3.92%, F 8.69%, N 16.01%, O 3.66%, S 7.33%.

Description and references

Ergosterol biosynthesis inhibitor. Prepn (stereochemistry unspecified): T. Naito et al, EP 667346; eidem, US 5648372 (1995, 1997 both to Eisai); of optically acitve form: A. Tsuruoka et al., Chem. Pharm. Bull. 46, 623 (1998). Chiral synthesis: Y. Kaku et al., ibid. 1125. In vitro comparative antifungal spectrum: J. C. Fung-Tomc et al., Antimicrob. Agents Chemother. 42, 313 1998. Antifungal activity in candidosis: K. V. Clemons, D. A. Stevens, ibid. 45, 3433 (2001); in aspergillosis: W. R. Kirkpatrick et al., J. Antimicrob. Chemother. 49, 353 (2002). Clinical evaluation in onychomycosis: A. K. Gupta et al., J. Eur. Acad. Dermatol. Venereol. 19, 437 (2005). Review of development and therapeutic potential: S. Arikan, J. H. Rex, Curr. Opin. Investig. Drugs 3, 555-561 (2002).

Chemical structure

Properties

Colorless prisms from diisopropyl ether/n-hexane, mp 164-166°. [α]D24 -29.1° (c = 1.03 in methanol).

Therapeutic Category

Antifungal.

Keywords

Antifungal (Synthetic); Triazoles