8137. Repinotan

Nomenclature

CAS number: 144980-29-0
2-[4-[[[(2R)-3,4-Dihydro-2H-1-benzopyran-2-yl]methyl]amino]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; R-(-)-2-[4-[(chroman-2-ylmethyl)amino]butyl]-1,1-dioxobenzo[d]isothiazolone; (-)-2-[N-[4-(1,1-dioxido-3-oxo-2,3-dihydrobenzisothiazol-2-yl)butyl]aminomethyl]chroman.
C21H24N2O4S; mol wt 400.49.
C 62.98%, H 6.04%, N 6.99%, O 15.98%, S 8.01%.

Description and references

Serotonin 5-HT1A-receptor agonist. Prepn: B. Junge et al., EP 352613; eidem, US 5137901 (1990, 1992 both to Bayer AG). Pharmacology and receptor binding study: J. De Vry et al., J. Pharmacol. Exp. Ther. 284, 1082 (1998). Neuroprotective effect in vitro and in vivo: I. Semkova et al., Eur. J. Pharmacol. 359, 251 (1998). Review: H. A. M. Mucke, Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs 1, 621-628 (1999).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 144980-77-8
Bay x 3702.
C21H24N2O4S.HCl; mol wt 436.95.
C 57.72%, H 5.77%, N 6.41%, O 14.65%, S 7.34%, Cl 8.11%.

Properties

mp 192-194°. [α]D -42.2° (c = 1 in trichloromethane).

Therapeutic Category

Neuroprotective.

Keywords

Neuroprotective; Serotonin Receptor Agonist