8138. Repirinast

Nomenclature

CAS number: 73080-51-0
5,6-Dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano[3,2-c]quinoline-2-carboxylic acid 3-methylbutyl ester; isopentyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4H-pyrano[3,2-c]quinoline-2-carboxylate; MY-5116; Romet (Mitsubishi).
C20H21NO5; mol wt 355.38.
C 67.59%, H 5.96%, N 3.94%, O 22.51%.

Description and references

Prepn: BE 876751; Y. Morinaka, K. Takahashi, US 4298610 (1979, 1981 both to Mitsubishi Yuka); Y. Morinaka et al., Eur. J. Med. Chem. - Chim. Ther. 16, 251 (1981). General pharmacology in animals: K. Takahashi et al., Oyo Yakuri 32, 233 (1986), C.A. 105, 218691j (1986). Anti-allergic effects: S. Kono, K. Ohata, Arerugi 35, 1105 (1986), C.A. 106, 165870z (1987). Toxicity: M. Nagase et al., Iyakuhin Kenkyu 17, 545 (1986), C.A. 106, 108121r (1987).

Chemical structure

Properties

Crystals from chloroform + n-hexane, mp 236-241°. LD50 in rats, mice (mg/kg): >5000 orally, >5000 s.c. both species (Nagase).

Therapeutic Category

Antiallergic.

Keywords

Antiallergic