8169. Reversine
Nomenclature
CAS number: 656820-32-5
N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine; 2-(4-morpholinoanilino)-6-cyclohexylaminopurine; 2-(4-morpholinoanilino)-N6-cyclohexyladenine. C21H27N7O; mol wt 393.49.
C 64.10%, H 6.92%, N 24.92%, O 4.07%.
Description and references
Synthetic small molecule reported to induce murine myoblasts to dedifferentiate into multipotent progenitor cells. Discovery of induction of cell dedifferentiation: S. Chen et al., J. Am. Chem. Soc. 126, 410 (2004). Prepn: S. Chen et al., WO 05047524; eidem, US 050176707 (both 2005 to Scripps); see also combinatorial synthesis method: S. Ding et al., J. Am. Chem. Soc. 124, 1594 (2002). A3 adenosine receptor antagonist activity: M. Perreira et al., J. Med. Chem. 48, 4910 (2005).
