8168. Revaprazan

Nomenclature

CAS number: 199463-33-7
4-(3,4-Dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-2-pyrimidinamine; 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine.
C22H23FN4; mol wt 362.44.
C 72.90%, H 6.40%, F 5.24%, N 15.46%.

Description and references

Gastric proton pump inhibitor. Prepn: J. W. Lee et al., WO 9605177; eidem, US 5750531 (1996, 1998 both to Yuhan). HPLC determn in plasma and urine: K. S. Han et al., J. Chromatogr. B 696, 312 (1997). Clinical pharmacokinetics: K.-S. Yu et al., J. Clin. Pharmacol. 44, 73 (2004).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 178307-42-1
YH-1885; Revanex (Yuhan).
C22H23FN4.HCl; mol wt 398.90.
C 66.24%, H 6.06%, F 4.76%, N 14.05%, Cl 8.89%.

Properties

mp 205-208°.

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative