8212. Ridogrel

Nomenclature

CAS number: 110140-89-1
5-[[(E)-[3-Pyridinyl[3-(trifluoromethyl)phenyl]methylene]amino]oxy]pentanoic acid; R-68070.
C18H17F3N2O3; mol wt 366.33.
C 59.02%, H 4.68%, F 15.56%, N 7.65%, O 13.10%.

Description and references

Combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist. Prepn: E. J. E. Freyne et al., EP 221601; eidem, US 4963573 (1987, 1990 both to Janssen). Clinical pharmacology: B. Hoet et al., Thromb. Haemostasis 64, 87 (1990); C. Weber et al., ibid. 68, 214 (1992). Clinical study in peripheral arterial obstructive disease: J. De Cree et al., Int. Angiol. 12, 59 (1993); as adjunct to thrombolysis in acute myocardial infarction: RAPT Investigators, Circulation 89, 588 (1994).

Chemical structure

Properties

Crystals from diisopropyl ether/hexane (2:1), mp 70.3°.

Therapeutic Category

Antithrombotic.

Keywords

Antithrombotic; Thromboxane A2-Receptor Antagonist; Thromboxane A2-Sythetase Inhibitor