8231. Rioprostil

Nomenclature

CAS number: 77287-05-9
(11α,13E)-1,11,16-Trihydroxy-16-methylprost-13-en-9-one; (2R,3R,4R)-4-hydroxy-2-(7-hydroxyheptyl)-3-[(E)-(4RS)-(4-hydroxy-4-methyl-1-octenyl)]cyclopentanone; 16-methyl-1,11α,16RS-trihydroxyprost-13E-en-9-one; Bay o 6893; ORF-15927; TR-4698; Rostil (Ortho).
C21H38O4; mol wt 354.52.
C 71.15%, H 10.80%, O 18.05%.

Description and references

Prostaglandin E1 analog with cytoprotective and gastric antisecretory activity. Prepn: H. C. Kluender et al., US 4132738 (1979 to Miles). Pharmacology: D. A. Shriver et al., Arzneim.-Forsch. 35, 839 (1985). Effect on human gastric secretion: P. Demol et al., ibid. 861; B. Vaona et al., Adv. Prostaglandin Thromboxane Leukotriene Res. 17, 328 (1987). Clinical evaluation in duodenal ulcer: H. G. Dammann et al., ibid. 303.

Chemical structure

Properties

[α]D -58.6° (c = 1 in chloroform).

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative; Prostaglandin/Prostaglandin Analog