8257. Ropinirole
Nomenclature
CAS number: 91374-21-9
4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one; 4-[2-(di-n-propylamino)ethyl]-2(3H)-indolone; SKF-101468. C16H24N2O; mol wt 260.37.
C 73.81%, H 9.29%, N 10.76%, O 6.14%.
Description and references
Selective dopamine D2-receptor agonist. Prepn: G. Gallagher, Jr., US 4452808 (1984 to Smithkline Beckman); idem et al., J. Med. Chem. 28, 1533 (1985). HPLC determn in plasma: J. E. Swagzdis, B. A. Mico, J. Pharm. Sci. 75, 90 (1986). Pharmacology and receptor binding study: R. J. Eden et al., Pharmacol. Biochem. Behav. 38, 147 (1991). Clinical pharmacology, pharmacokinetics: C. de Mey et al., Br. J. Clin. Pharmacol. 32, 483 (1991). Review of clinical experience in Parkinson's disease: R. Pahwa et al., Expert Rev. Neurother. 4, 581-588 (2004); in restless legs syndrome: C. Trenkwalder, Eur. J. Neurol. 13, Suppl. 3, 21-30 (2006).
Derivative
Hydrochloride.Nomenclature
CAS number: 91374-20-8
SKF-101468A; Requip (GSK). C16H24N2O.HCl; mol wt 296.84.
C 64.74%, H 8.49%, N 9.44%, O 5.39%, Cl 11.94%.
Properties
Crystals from acetonitrile, mp 241-243°.Therapeutic Category
Antiparkinsonian. In treatment of restless legs syndrome.
Keywords
Antiparkinsonian; Dopamine Receptor Agonist