8259. Roquinimex

Nomenclature

CAS number: 84088-42-6
1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide; N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide; 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilide; LS-2616; Linomide (Pfizer).
C18H16N2O3; mol wt 308.33.
C 70.12%, H 5.23%, N 9.09%, O 15.57%.

Description and references

Biological response modifier. Prepn: E. Eriksoo et al., EP 59698; eidem, US 4738971 (1982, 1988 both to AB Leo). Immunopharmacology: A. Tarkowski et al., Immunology 59, 589 (1986). Mechanism of action study: E.-L. Larsson et al., Int. J. Immunopharmacol. 9, 425 (1987). Clinical evaluation in cancer patients: J. C. S. Bergh et al., Cancer Invest. 15, 204 (1997).

Chemical structure

Properties

Crystals from pyridine, mp 200-204°.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Immunomodulators