8260. Rosaprostol

Nomenclature

CAS number: 56695-65-9
2-Hexyl-5-hydroxycyclopentaneheptanoic acid; 9-hydroxy-19,20-bisnorprostanoic acid; C-83; IBI-C83; Rosal (IBI).
C18H34O3; mol wt 298.46.
C 72.44%, H 11.48%, O 16.08%.

Description and references

Prostaglandin analog. Prepn, hypolipemic, platelet aggregation inhibitory activity: U. Valcavi, DE 2535343, eidem, US 4073938 (1976, 1978 both to Ist. Biochim. Ital.). Alternate process: V. Marotta, G. Zabban, EP 155392 (1985 to Ist. Biochim. Ital.). Gastric antisecretory, cytoprotective activity: U. Valcavi et al., Arzneim.-Forsch. 32, 657 (1982). Effect on mucus and gastrin secretion in duodenal ulcer: D. Foschi et al., Prostaglandins Leukotrienes Med. 15, 147 (1984). Comparison with cimetidine, q.v.: eidem, Drugs Exp. Clin. Res. 10, 427 (1984). Clinical evaluation in treatment of ulcers: G. P. Tincani et al., Minerva Med. 78, 847 (1987).

Chemical structure

Properties

Oil.

Derivative

Sodium salt.

Nomenclature

CAS number: 56695-66-0
C18H33NaO3; mol wt 320.44.
C 67.47%, H 10.38%, Na 7.17%, O 14.98%.

Properties

White solid. LD50 orally in mice: ≈3000 mg/kg (Valcavi, 1978); orally in rats: >5 g/kg (Valcavi, 1982).

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative; Prostaglandin/Prostaglandin Analog