8309. Sabcomeline
Nomenclature
CAS number: 159912-53-5
R-(Z)-α-(Methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitrile; SB-202026. C10H15N3O; mol wt 193.25.
C 62.15%, H 7.82%, N 21.74%, O 8.28%.
Description and references
Selective muscarinic M1-receptor partial agonist. Prepn: B. S. Orlek et al., EP 392803; eidem, US 5278170; (1990, 1994 both to Beecham); S. M. Bromidge et al., J. Med. Chem. 40, 4265 (1997). Pharmacology: J. M. Loudon et al., J. Pharmacol. Exp. Ther. 283, 1059 (1997). Cognition improvement in rats: H. Hodges et al., Behav. Brain Res. 99, 81 (1999).
Properties
White crystals from methanol-acetone, mp 154-156°. [α]D20 +14.4° (c = 0.424 in EtOH).Derivative
Hydrochloride.Nomenclature
CAS number: 159912-58-0
Memric (GSK). C10H15N3O.HCl; mol wt 229.71.
C 52.29%, H 7.02%, N 18.29%, O 6.97%, Cl 15.43%.
Properties
mp 218-219°. [α]D20 +25.3° (c = 1.00 in EtOH).Therapeutic Category
Nootropic
Keywords
Nootropic