8310. Sabeluzole

Nomenclature

CAS number: 104383-17-7
4-(2-Benzothiazolylmethylamino)-α-[(4-fluorophenoxy)methyl]-1-piperidineethanol; N-methyl-N-[1-[3-(4-fluorophenoxy)-2-hydroxypropyl]piperidin-4-yl]benzothiazole-2-amine; R-58735.
C22H26FN3O2S; mol wt 415.52.
C 63.59%, H 6.31%, F 4.57%, N 10.11%, O 7.70%, S 7.72%.

Description and references

Prepn: R. A. Stokbroekx et al., EP 184257 (1986 to Janssen). Pharmacology: A. Wauquier et al., Drug Dev. Res. 8, 373 (1986). Comparative activity of racemate and enantiomers: L. Werbrouck et al., ibid. 24, 41 (1991). Clinical pharmacokinetics: P. P. DeDeyn et al., Eur. J. Clin. Pharmacol. 43, 661 (1992). Clinical evaluation of effects on memory functions: G. H. C. Clincke et al., Psychopharmacology 94, 52 (1988). Clinical studies in age-associated memory impairment: L. Tritsmans et al., Drug Dev. Res. 20, 473 (1990); G. Clincke et al., ibid. 23, 301 (1991); in memory functions of epileptics: A. P. Aldenkamp et al., Neuropsychobiology 32, 37 (1995).

Chemical structure

Properties

mp 101.7°.

Therapeutic Category

Nootropic.

Keywords

Nootropic