8419. Secnidazole

Nomenclature

CAS number: 3366-95-8
α,2-Dimethyl-5-nitro-1H-imidazole-1-ethanol; 1-(2-hydroxypropyl)-2-methyl-5-nitroimidazole; 1-(2-methyl-5-nitroimidazol-1-yl)-2-propanol; PM-185184; RP-14539; Flagentyl (Rh^one-Poulenc).
C7H11N3O3; mol wt 185.18.
C 45.40%, H 5.99%, N 22.69%, O 25.92%.

Description and references

Analog of metronidazole, q.v. Prepn: FR M3270 (1965 to Rh^one-Poulenc), C.A. 63, 11571d (1965); C. Cosar et al., Arzneim.-Forsch. 16, 23 (1966). Anti-amebic and trichomonacidal activities: F. Benazet, L. Guillaume, Bull. Soc. Pathol. Exot. Ses Fil. 69, 309 (1976), C.A. 90, 145922v (1979). Serum half-life: J. Symonds, J. Antimicrob. Chemother. 5, 484 (1979). Therapeutic use: D. Videau et al., Br. J. Vener. Dis. 54, 77 (1978).

Chemical structure

Properties

Cryst from toluene, mp 76° (Cosar).

Therapeutic Category

Antiamebic. Antiprotozoal (Trichomonas).

Keywords

Antiamebic; Antiprotozoal (Trichomonas)