Description and references

Polymeric non-absorbed phosphate binder consisting of polyallylamine crosslinked with epichlorohydrin to form a hydrogel where 40% of the amines are protonated. Follows the general formula of (C₃H₇N.C₃H₅ClO)_n. Binds dietary phosphate leading to increased fecal excretion, decreased absorption and decreased serum phosphorous levels. Prepd not claimed: S. R. Holmes-Farley et al., WO 9505184; eidem, US 5496545 (1995, 1996 both to GelTex). Mechanism of action: S. R. Holmes-Farley et al., J. Macromol. Sci. Pure Appl. Chem. A36, 1085 (1999). Determn of phosphate binding capacity: J. R. Mazzeo et al., J. Pharm. Biomed. Anal. 19, 911 (1999). Clinical studies in end stage renal disease: E. A. Slatopolsky et al., Kidney Int. 55, 299 (1999). Review of clinical applications: J. Henderson, P. Altmann, Nephron Clin. Pract. 94, 53-58 (2003).

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Derivative