8475. Sevoflurane

Nomenclature

CAS number: 28523-86-6
1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane; fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether; SevoFlo (Abbott); Sevofrane (Maruishi); Sevorane (Abbott); Ultane (Abbott).
C4H3F7O; mol wt 200.05.
C 24.02%, H 1.51%, F 66.48%, O 8.00%.

Description and references

Rapid-acting inhalational anesthetic. Prepn: B. M. Regan, J. C. Longstreet, DE 1954268; eidem, US 3689571 (1970, 1972 both to Baxter Labs.). Pharmacology and physicochemical properties: R. F. Wallin et al., Anesth. Analg. 54, 758 (1975). Clinical pharmacology and metabolism: D. A. Holaday, F. R. Smith, Anesthesiology 54, 100 (1981). Toxicity study: D. P. Strum et al., Anesth. Analg. 66, 769 (1987). Minimum alveolar concentration (MAC) in humans: T. Katoh, K. Ikeda, Anesthesiology 66, 301 (1987). NMR studies: E. Maciega et al., J. Mol. Struct. 785, 139 (2006). Clinical trial in maintenance of anesthesia: C. Campbell et al., J. Clin. Anesth. 8, 557 (1996). Review of use in adult day-case anesthesia: S. Ghatge et al., 47, 917-931 (2003).

Chemical structure

Properties

Volatile liquid, bp751 58.1-58.2°; bp760 58.6°. d423 1.505 d20 1.520-1.525. Vapor pressure (mm Hg): 317 (36°); 197 (25°); 157 (20°). Nonflammable in air at ambient temps; flammability limit in O2: 11 vol. percent; in N2O: 10 vol. percent. Partition coefficient at 37° (blood/gas): 0.63-0.69; (water/gas): 0.36; (olive oil/gas): 47-54; (brain/gas): 1.15.

Therapeutic Category

Anesthetic (inhalation).

Therapeutic Category (Veterinary)

Anesthetic (inhalation).

Keywords

Anesthetic (Inhalation)