Prepn and properties: Gmelins, Sodium (8th ed.) 21, 799-801 (1928) and supplement, part 4, 1382-1386 (1967). Used experimentally in treatment of sickle cell anemia. Effect of cyanate on sickling: May et al., Lancet 1, 658 (1972); P. N. Gillette et al., N. Engl. J. Med. 290, 654 (1974). Pharmacology and toxicology: Cerami et al. J. Pharmacol. Exp. Ther. 185, 653 (1973). Clinical studies: Peterson et al., ibid. 189, 577 (1974).